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Independent clinical studies have demonstrated that combustible cigarettes containing 22nd Centurys VLN tobacco with non-addictive levels (0.04mg/stick yield per machine smoking) of nicotine enable smokers to disassociate the act of smoking from the rapid intake of nicotine

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It, therefore, becomes important to differentiate between clinically insignificant and clinically significant color changes, hence providing a clear benchmark in esthetic integrity evaluation for materials under study conditions 18,24,51

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